منابع مشابه
Oxidized LDL and HDL: antagonists in atherothrombosis.
Increased LDL oxidation is associated with coronary artery disease. The predictive value of circulating oxidized LDL is additive to the Global Risk Assessment Score for cardiovascular risk prediction based on age, gender, total and HDL cholesterol, diabetes, hypertension, and smoking. Circulating oxidized LDL does not originate from extensive metal ion-induced oxidation in the blood but from mi...
متن کاملOxidized HDL: the paradox-idation of lipoproteins.
The strong inverse relationship between HDL level and risk for coronary artery disease has been attributed to different mechanisms. More than 30 years ago, Glomset1 proposed that HDL mediates the transfer of cholesterol from peripheral tissues to the liver, where the sterol and its oxygenated products are excreted into the bile. Subsequent studies demonstrated that HDL accepts cholesterol from ...
متن کاملInflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells
The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
متن کاملDefective metabolism of oxidized phospholipid by HDL from people with type 2 diabetes.
HDL protects against atherosclerosis development. Defective functioning of HDL in type 2 diabetes may be one cause of increased cardiovascular disease associated with type 2 diabetes. HDL modulates LDL oxidation through the action of paraoxonase-1 (PON1), which is one of the major mechanisms by which HDL is antiatherogenic. We have compared the ability of HDL from people with type 2 diabetes (n...
متن کاملHost-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.
Intracellular pathogens survive by evading the host immune system and accessing host metabolic pathways to obtain nutrients for their growth. Mycobacterium leprae, the causative agent of leprosy, is thought to be the mycobacterium most dependent on host metabolic pathways, including host-derived lipids. Although fatty acids and phospholipids accumulate in the lesions of individuals with the lep...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2003
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000090570.99836.9c